[123I] FP‐CIT spect study in vascular parkinsonism and Parkinson's disease
Identifieur interne : 000F12 ( Main/Exploration ); précédent : 000F11; suivant : 000F13[123I] FP‐CIT spect study in vascular parkinsonism and Parkinson's disease
Auteurs : Jan Zijlmans [Royaume-Uni, Pays-Bas] ; Andrew Evans [Royaume-Uni] ; Flavia Fontes [Royaume-Uni] ; Regina Katzenschlager [Royaume-Uni, Autriche] ; Svetoslav Gacinovic [Royaume-Uni] ; Andrew Lees (neurologue) [Royaume-Uni] ; Durval Costa [Royaume-Uni, Portugal]Source :
- Movement Disorders [ 0885-3185 ] ; 2007-07-15.
English descriptors
Abstract
There is substantial evidence to support a role for small vessel disease (SVD) as a cause for vascular parkinsonism (VP). Using [123I] FP‐CIT SPECT (single photon emission computed tomography), we have tried to determine whether VP patients have pre‐synaptic dopaminergic function similar to PD patients, and whether the severity of parkinsonian symptoms as well as the levodopa response in VP patients are correlated with pre‐synaptic dopaminergic dysfunction. Thirteen patients fulfilling operational clinical criteria for VP had [123I] FP‐CIT scans. Mean [123I] FP‐CIT uptake in the basal ganglia was significantly lower in VP patients than in healthy controls, and the asymmetry index was not significantly different between these groups. In contrast, compared with the PD group, only the mean asymmetry index was significantly lower in VP patients. None of the parameters measured was significantly different between VP patients who had an insidious onset of parkinsonism (VPi) and those who had an acute onset (VPa). There was a significant correlation between the bilateral basal ganglia FP‐CIT uptake reduction in the VP patients and UPDRS motor scores, but not with the mean % reduction in motor UPDRS after levodopa. We suggest that in the majority of VP patients, pre‐synaptic dopaminergic function is reduced. The presence of a rather symmetrical FP‐CIT uptake in the basal ganglia may help to distinguish VP from PD and could therefore be used as a criterion for the clinical diagnosis of VP. © 2007 Movement Disorder Society
Url:
DOI: 10.1002/mds.21479
Affiliations:
- Autriche, Pays-Bas, Portugal, Royaume-Uni
- Angleterre, Grand Londres, Vienne (Autriche)
- Londres, Vienne (Autriche)
- National Hospital for Neurology and Neurosurgery
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">[123I] FP‐CIT spect study in vascular parkinsonism and Parkinson's disease</title><author><name sortKey="Zijlmans, Jan" sort="Zijlmans, Jan" uniqKey="Zijlmans J" first="Jan" last="Zijlmans">Jan Zijlmans</name></author><author><name sortKey="Evans, Andrew" sort="Evans, Andrew" uniqKey="Evans A" first="Andrew" last="Evans">Andrew Evans</name></author><author><name sortKey="Fontes, Flavia" sort="Fontes, Flavia" uniqKey="Fontes F" first="Flavia" last="Fontes">Flavia Fontes</name></author><author><name sortKey="Katzenschlager, Regina" sort="Katzenschlager, Regina" uniqKey="Katzenschlager R" first="Regina" last="Katzenschlager">Regina Katzenschlager</name></author><author><name sortKey="Gacinovic, Svetoslav" sort="Gacinovic, Svetoslav" uniqKey="Gacinovic S" first="Svetoslav" last="Gacinovic">Svetoslav Gacinovic</name></author><author><name sortKey="Lees, Andrew J" sort="Lees, Andrew J" uniqKey="Lees A" first="Andrew J" last="Lees">Andrew Lees (neurologue)</name><affiliation><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName>National Hospital for Neurology and Neurosurgery</orgName></affiliation></author><author><name sortKey="Costa, Durval" sort="Costa, Durval" uniqKey="Costa D" first="Durval" last="Costa">Durval Costa</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:E079B40BEFB56C7F11BEB352B18840E6DBD7BFAD</idno><date when="2007" year="2007">2007</date><idno type="doi">10.1002/mds.21479</idno><idno type="url">https://api.istex.fr/document/E079B40BEFB56C7F11BEB352B18840E6DBD7BFAD/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">002D76</idno><idno type="wicri:Area/Main/Curation">002998</idno><idno type="wicri:Area/Main/Exploration">000F12</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">[123I] FP‐CIT spect study in vascular parkinsonism and Parkinson's disease</title><author><name sortKey="Zijlmans, Jan" sort="Zijlmans, Jan" uniqKey="Zijlmans J" first="Jan" last="Zijlmans">Jan Zijlmans</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>National Hospital for Neurology and Neurosurgery, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Reta Lila Weston Institute of Neurological Studies, University College London</wicri:regionArea><wicri:noRegion>University College London</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Neurology, Amphia Hospital, Breda</wicri:regionArea><wicri:noRegion>Breda</wicri:noRegion></affiliation></author><author><name sortKey="Evans, Andrew" sort="Evans, Andrew" uniqKey="Evans A" first="Andrew" last="Evans">Andrew Evans</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>National Hospital for Neurology and Neurosurgery, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Reta Lila Weston Institute of Neurological Studies, University College London</wicri:regionArea><wicri:noRegion>University College London</wicri:noRegion></affiliation></author><author><name sortKey="Fontes, Flavia" sort="Fontes, Flavia" uniqKey="Fontes F" first="Flavia" last="Fontes">Flavia Fontes</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Nuclear Medicine, UCL, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Katzenschlager, Regina" sort="Katzenschlager, Regina" uniqKey="Katzenschlager R" first="Regina" last="Katzenschlager">Regina Katzenschlager</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>National Hospital for Neurology and Neurosurgery, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Reta Lila Weston Institute of Neurological Studies, University College London</wicri:regionArea><wicri:noRegion>University College London</wicri:noRegion></affiliation><affiliation wicri:level="3"><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Neurology, Donauspital/ SMZ Ost, Vienna</wicri:regionArea><placeName><settlement type="city">Vienne (Autriche)</settlement><region nuts="2" type="province">Vienne (Autriche)</region></placeName></affiliation></author><author><name sortKey="Gacinovic, Svetoslav" sort="Gacinovic, Svetoslav" uniqKey="Gacinovic S" first="Svetoslav" last="Gacinovic">Svetoslav Gacinovic</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Nuclear Medicine, UCL, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Lees, Andrew J" sort="Lees, Andrew J" uniqKey="Lees A" first="Andrew J" last="Lees">Andrew Lees (neurologue)</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>National Hospital for Neurology and Neurosurgery, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName>National Hospital for Neurology and Neurosurgery</orgName></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Reta Lila Weston Institute of Neurological Studies, University College London</wicri:regionArea><wicri:noRegion>University College London</wicri:noRegion><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName>National Hospital for Neurology and Neurosurgery</orgName></affiliation></author><author><name sortKey="Costa, Durval" sort="Costa, Durval" uniqKey="Costa D" first="Durval" last="Costa">Durval Costa</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Nuclear Medicine, UCL, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Portugal</country><wicri:regionArea>HPP Medicina Molecular, SA, Porto</wicri:regionArea><wicri:noRegion>Porto</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2007-07-15">2007-07-15</date><biblScope unit="volume">22</biblScope><biblScope unit="issue">9</biblScope><biblScope unit="page" from="1278">1278</biblScope><biblScope unit="page" to="1285">1285</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">E079B40BEFB56C7F11BEB352B18840E6DBD7BFAD</idno><idno type="DOI">10.1002/mds.21479</idno><idno type="ArticleID">MDS21479</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>FP‐CIT SPECT</term><term>L‐dopa challenge</term><term>criteria</term><term>vascular parkinsonism</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">There is substantial evidence to support a role for small vessel disease (SVD) as a cause for vascular parkinsonism (VP). Using [123I] FP‐CIT SPECT (single photon emission computed tomography), we have tried to determine whether VP patients have pre‐synaptic dopaminergic function similar to PD patients, and whether the severity of parkinsonian symptoms as well as the levodopa response in VP patients are correlated with pre‐synaptic dopaminergic dysfunction. Thirteen patients fulfilling operational clinical criteria for VP had [123I] FP‐CIT scans. Mean [123I] FP‐CIT uptake in the basal ganglia was significantly lower in VP patients than in healthy controls, and the asymmetry index was not significantly different between these groups. In contrast, compared with the PD group, only the mean asymmetry index was significantly lower in VP patients. None of the parameters measured was significantly different between VP patients who had an insidious onset of parkinsonism (VPi) and those who had an acute onset (VPa). There was a significant correlation between the bilateral basal ganglia FP‐CIT uptake reduction in the VP patients and UPDRS motor scores, but not with the mean % reduction in motor UPDRS after levodopa. We suggest that in the majority of VP patients, pre‐synaptic dopaminergic function is reduced. The presence of a rather symmetrical FP‐CIT uptake in the basal ganglia may help to distinguish VP from PD and could therefore be used as a criterion for the clinical diagnosis of VP. © 2007 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Autriche</li><li>Pays-Bas</li><li>Portugal</li><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Grand Londres</li><li>Vienne (Autriche)</li></region><settlement><li>Londres</li><li>Vienne (Autriche)</li></settlement><orgName><li>National Hospital for Neurology and Neurosurgery</li></orgName></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Zijlmans, Jan" sort="Zijlmans, Jan" uniqKey="Zijlmans J" first="Jan" last="Zijlmans">Jan Zijlmans</name></region><name sortKey="Costa, Durval" sort="Costa, Durval" uniqKey="Costa D" first="Durval" last="Costa">Durval Costa</name><name sortKey="Evans, Andrew" sort="Evans, Andrew" uniqKey="Evans A" first="Andrew" last="Evans">Andrew Evans</name><name sortKey="Evans, Andrew" sort="Evans, Andrew" uniqKey="Evans A" first="Andrew" last="Evans">Andrew Evans</name><name sortKey="Fontes, Flavia" sort="Fontes, Flavia" uniqKey="Fontes F" first="Flavia" last="Fontes">Flavia Fontes</name><name sortKey="Gacinovic, Svetoslav" sort="Gacinovic, Svetoslav" uniqKey="Gacinovic S" first="Svetoslav" last="Gacinovic">Svetoslav Gacinovic</name><name sortKey="Katzenschlager, Regina" sort="Katzenschlager, Regina" uniqKey="Katzenschlager R" first="Regina" last="Katzenschlager">Regina Katzenschlager</name><name sortKey="Katzenschlager, Regina" sort="Katzenschlager, Regina" uniqKey="Katzenschlager R" first="Regina" last="Katzenschlager">Regina Katzenschlager</name><name sortKey="Lees, Andrew J" sort="Lees, Andrew J" uniqKey="Lees A" first="Andrew J" last="Lees">Andrew Lees (neurologue)</name><name sortKey="Lees, Andrew J" sort="Lees, Andrew J" uniqKey="Lees A" first="Andrew J" last="Lees">Andrew Lees (neurologue)</name><name sortKey="Zijlmans, Jan" sort="Zijlmans, Jan" uniqKey="Zijlmans J" first="Jan" last="Zijlmans">Jan Zijlmans</name></country><country name="Pays-Bas"><noRegion><name sortKey="Zijlmans, Jan" sort="Zijlmans, Jan" uniqKey="Zijlmans J" first="Jan" last="Zijlmans">Jan Zijlmans</name></noRegion></country><country name="Autriche"><region name="Vienne (Autriche)"><name sortKey="Katzenschlager, Regina" sort="Katzenschlager, Regina" uniqKey="Katzenschlager R" first="Regina" last="Katzenschlager">Regina Katzenschlager</name></region></country><country name="Portugal"><noRegion><name sortKey="Costa, Durval" sort="Costa, Durval" uniqKey="Costa D" first="Durval" last="Costa">Durval Costa</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000F12 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000F12 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:E079B40BEFB56C7F11BEB352B18840E6DBD7BFAD
|texte= [123I] FP‐CIT spect study in vascular parkinsonism and Parkinson's disease
}}
| This area was generated with Dilib version V0.6.23. |  |